Sparing a little may save a lot

Sparing a little may save a lot: lessons from the Studies of Left Ventricular Dysfunction (SOLVD).

Over the past 20 years, attention to the renin-angiotensinaldosterone system has brought marked success in the treatment of heart failure (HF). With the publication of the Randomized Aldactone Evaluation Study (RALES) trial, spironolactone became another cornerstone of therapy for the treatment of patients with New York Heart Association (NYHA) functional class III to IV HF (1). Based on the st...

Spending a little to save a lot

Phase III studies of disease-modifying agents for neurodegenerative disorders generally require hun­ dreds of patients to be followed for at least 2 years at a cost of millions of dollars. No matter how promis­ ing an agent may appear in preclinical studies and animal models, preliminary evidence that the treat­ ment is likely to be helpful in patients (proof-of­ concept) and that it is reasona...

Futility studies: spending a little to save a lot.

published by admin on Mon, 09/08/2014 3:07pm Title Futility studies: spending a little to save a lot. Publication Type Journal Article Year of Publication 2006 Authors Schwid, SR, Cutter, GR Journal Neurology Volume 66 Issue 5 Pagination 626-7 Date Published 2006 Mar 14 ISSN 1526-632X

A Little Knowledge (plus a Lot of Information) May Be a Very Da

Here, I address two other problems raised by this article. A review of published experimental results led the authors to conclude that “diversity enhanced ecosystem stability”, where this is defined as “the ability to withstand recurrent perturbations”. This curious statement reverses modern theory of ecological diversity in the ocean as discussed, for instance, by Ramón Margalef. Ecosystems of...

Give a little ... get a lot.